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An organism’s ability to regulate gene expression in response to environmental factors such as nutrition levels and oxygen availabi lity is critical for survival. Previous research has implicated sirtuin genes , which transcribe deacetylase pr oteins that regulate gene expression via deacetylase of either histone proteins or other proteins , in regulation of both oxygen and nutrient availability in mice . This resear ch knocks down sirtuins in the dietary restriction pathway and the hypoxic response pathways in order to examine whether these molecular pathways act in a sirtuin - dependent mechanism in Caenorhabditis elegans . The findings showed that in both pathways, kno ckdown of sirtuin - dependent gene express ion led to a decreased lifespan but di d not mirror the li fespan of the worm strains that were either sirtuin mutant strains or sirtuin RNAi knockdown s in wild type worm strains . This indicates that both pathways are not sirtuin - dependent , although the mechanism of how these pathways increase longevity remains unclear . These findings point to t he need for further research in to the role of sirtuin genes within the cell and whether they actually function as longevity genes.
Longevity -- Genetics, Caenorhabditis elegans, Histone deacetylase, Aging -- Genetic factors, Caloric Restriction, Mutation (Biology), Gene expression, Sirtuins, Whitman College 2011 -- Dissertation collection -- Biology Department
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Brice, Jessica Alexandra, "Role of sirtuin genes in longevity" (2011). Honors Theses. 44.
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