Title

The Role of Regulatory T Cells in Immune Responses to Influenza

Presenter

Sarah Krawczak

Abstract

Regulatory T cells (Tregs) make up a population of T cells in the immune system that are crucial for preventing autoimmunity and promoting immune homeostasis. It is well established that during infection Tregs function to prevent autoimmunity and dampen over exuberant immune responses. Although less well known, it is hypothesized that Tregs also play an important role in the facilitation of pathogen clearance. Here we explore this hypothesis by analyzing how Tregs function in immune responses to influenza, a virus that affects 5 million people across the world annually. Specifically, we examine how immune responses to influenza virus are impaired in the absence of regulatory T cells, and evaluate mechanisms that could lead to the observed impairment.

Faculty Sponsor

Kendra Golden

Sponsor Department/Programs

Biochemistry, Biophysics and Molecular Biology

Tracks

Cells and Sickness

Terms of Use

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Location

Science 100

Presentation Type

Oral Presentation

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Apr 12th, 9:00 AM Apr 11th, 9:15 AM

The Role of Regulatory T Cells in Immune Responses to Influenza

Science 100

Regulatory T cells (Tregs) make up a population of T cells in the immune system that are crucial for preventing autoimmunity and promoting immune homeostasis. It is well established that during infection Tregs function to prevent autoimmunity and dampen over exuberant immune responses. Although less well known, it is hypothesized that Tregs also play an important role in the facilitation of pathogen clearance. Here we explore this hypothesis by analyzing how Tregs function in immune responses to influenza, a virus that affects 5 million people across the world annually. Specifically, we examine how immune responses to influenza virus are impaired in the absence of regulatory T cells, and evaluate mechanisms that could lead to the observed impairment.

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