Title

Adjuvant Stability and Performance in Human Whole Blood

Presenter

Brandon Paris

Abstract

Modern vaccines have come to rely on the use of adjuvants for their efficacy in eliciting a robust immune response. Adjuvant formulations typically contain molecules that encapsulate the vaccine and allow it to pass through membranes more effectively, and/ or immunostimulatory molecules that strengthen the immune system’s response to the vaccine, thus allowing for lower dosages to extend the vaccine supply. Adjuvant formulations routinely go through stability tests and in vivo tests in mice. The purpose of this study is to understand the behavior of the adjuvant formulations ex vivo in human whole blood, by measuring cytokine levels and comparing these responses to the stability results.

Faculty Sponsor

James Russo, Jeff Broqn

Sponsor Department/Programs

Biochemistry, Biophysics and Molecular Biology

Tracks

Poster Session

Location

Cordiner Hall

Presentation Type

Poster

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Apr 19th, 1:00 PM Apr 19th, 2:00 PM

Adjuvant Stability and Performance in Human Whole Blood

Cordiner Hall

Modern vaccines have come to rely on the use of adjuvants for their efficacy in eliciting a robust immune response. Adjuvant formulations typically contain molecules that encapsulate the vaccine and allow it to pass through membranes more effectively, and/ or immunostimulatory molecules that strengthen the immune system’s response to the vaccine, thus allowing for lower dosages to extend the vaccine supply. Adjuvant formulations routinely go through stability tests and in vivo tests in mice. The purpose of this study is to understand the behavior of the adjuvant formulations ex vivo in human whole blood, by measuring cytokine levels and comparing these responses to the stability results.