Title

Uncovering Unknown Gonad Development Mechanisms

Presenter

Phillip Locklear

Abstract

Proper gonad development is essential for successful reproduction. Gonad development has been studied but the mechanisms involved are not fully understood. I used C. elegans as a model to study how the gonad is formed, by disrupting genes that may be involved. One of those genes is cdk-1, a cyclin-dependent kinase that is essential for cell division, because cdk-1 is required for the initiation of gonad development. How does cdk-1 control the initiation of gonad development? What other proteins does CDK-1 interact with? Cyclin-dependent kinases require cyclins to function and CDK-1 is known to interact with several cyclins. I sought to determine which of these cyclins CDK-1 interacts with to control initiation of gonad development by knocking down each cyclin by RNAi and looking for cdk-1 absence of gonads phenotype. I will also look at cdk-1 inhibitors and targets and shed some light on the control of reproductive development.

Faculty Sponsor

Matthew Crook

Sponsor Department/Programs

Biology

Tracks

Poster Session

Location

Cordiner Hall

Presentation Type

Poster

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Apr 19th, 1:00 PM Apr 19th, 2:00 PM

Uncovering Unknown Gonad Development Mechanisms

Cordiner Hall

Proper gonad development is essential for successful reproduction. Gonad development has been studied but the mechanisms involved are not fully understood. I used C. elegans as a model to study how the gonad is formed, by disrupting genes that may be involved. One of those genes is cdk-1, a cyclin-dependent kinase that is essential for cell division, because cdk-1 is required for the initiation of gonad development. How does cdk-1 control the initiation of gonad development? What other proteins does CDK-1 interact with? Cyclin-dependent kinases require cyclins to function and CDK-1 is known to interact with several cyclins. I sought to determine which of these cyclins CDK-1 interacts with to control initiation of gonad development by knocking down each cyclin by RNAi and looking for cdk-1 absence of gonads phenotype. I will also look at cdk-1 inhibitors and targets and shed some light on the control of reproductive development.