Title

Role of Cdk-2 in LET-23 Mediated Suppression of Cell Death

Presenter

Rachelle Hancock

Abstract

Characterizing cell signaling pathways involved in suppressing cell death has important significance in understanding cancer and neurodegenerative diseases. Cell death suppression can be investigated through the use of animal model organisms, such as Caenorhaditis elegans. LET-23 is the receptor in the epidermal growth factor (EGF) signaling pathway that is critical for multiple developmental processes. In addition, a novel role for LET-23 in suppression of cell death was recently discovered. How does LET-23 suppress cell death? We found that cdk-2, a cyclin dependant kinase that plays a critical role in the cell cycle, is necessary for the LET-23 mediated suppression of cell death. What is the mechanism of cdk-2 in LET-23 cell death suppression? What proteins does cdk-2 interact with in this process? To answer these questions we will knock down cyclin E, a cdk-2 binding partner, as well as cdk-2 inhibitors and targets using RNAi.

Faculty Sponsor

Matthew Crook

Sponsor Department/Programs

Biology

Tracks

Poster Session

Location

Cordiner Hall

Presentation Type

Poster

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Apr 19th, 1:00 PM Apr 19th, 2:00 PM

Role of Cdk-2 in LET-23 Mediated Suppression of Cell Death

Cordiner Hall

Characterizing cell signaling pathways involved in suppressing cell death has important significance in understanding cancer and neurodegenerative diseases. Cell death suppression can be investigated through the use of animal model organisms, such as Caenorhaditis elegans. LET-23 is the receptor in the epidermal growth factor (EGF) signaling pathway that is critical for multiple developmental processes. In addition, a novel role for LET-23 in suppression of cell death was recently discovered. How does LET-23 suppress cell death? We found that cdk-2, a cyclin dependant kinase that plays a critical role in the cell cycle, is necessary for the LET-23 mediated suppression of cell death. What is the mechanism of cdk-2 in LET-23 cell death suppression? What proteins does cdk-2 interact with in this process? To answer these questions we will knock down cyclin E, a cdk-2 binding partner, as well as cdk-2 inhibitors and targets using RNAi.