Title

The Role of Cell Cycle Control Genes in Gonad Development in the Roundworm Caenorhabditis elegans

Abstract

How does a single cell develop through a series of cell divisions into a multicellular organism, complete with nervous, reproductive and digestive systems? Many of the steps along this developmental journey have been elucidated, but one of the hardest to study is organogenesis, the formation of organs. We are using the model organism Caenorhabditis elegans to study the control of gonad development. We have characterized four cell cycle genes; cdk-1, plk-1, bub-1 and wee-1.3 that are required for different stages of gonad development. We are working to connect these genes to other members of their pathways and to fully understand their individual roles in gonad development. Our work is the beginning of our journey to understand gonad development in C. elegans and organogenesis in general. We will present our latest understanding of the complex process leading to the successful development of the C. elegans gonad.

Faculty Sponsor

Matthew Crook

Tracks

Animal Behavior

Terms of Use

ARMINDA Terms of Use

Location

Science 100

Presentation Type

Oral Presentation

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The Role of Cell Cycle Control Genes in Gonad Development in the Roundworm Caenorhabditis elegans

Science 100

How does a single cell develop through a series of cell divisions into a multicellular organism, complete with nervous, reproductive and digestive systems? Many of the steps along this developmental journey have been elucidated, but one of the hardest to study is organogenesis, the formation of organs. We are using the model organism Caenorhabditis elegans to study the control of gonad development. We have characterized four cell cycle genes; cdk-1, plk-1, bub-1 and wee-1.3 that are required for different stages of gonad development. We are working to connect these genes to other members of their pathways and to fully understand their individual roles in gonad development. Our work is the beginning of our journey to understand gonad development in C. elegans and organogenesis in general. We will present our latest understanding of the complex process leading to the successful development of the C. elegans gonad.

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