Title

Associations Between the Ankle-Brachial Index and Markers of Arterial Dysfunction and Non-Classical Monocytes in HIV-Infected Individuals

Abstract

Prevalence rates of peripheral arterial disease, a common vascular disease indicative of plaque buildup, have been reported in HIV-infected populations to be as high as 20.7 percent. Although the direct cause is still unknown, many factors have been attributed to this increased risk, including persistent inflammation and immune activation, as well as treatment side effects. Peripheral arterial disease is commonly diagnosed using the ankle-brachial index, which measures a ratio of blood pressures in the limbs. My presentation investigates potential associations between the ankle-brachial index and measurements of arterial dysfunction as well as non-classical monocytes. Results of our research showed that abnormal ankle-brachial index scores were significantly associated with lower levels of non-classical monocytes and increased carotid artery intima-media thickness. This research provides further understanding of the potential role that non-classical monocytes play in the progression of atherosclerosis in HIV-infected individuals.

Faculty Sponsor

Matt Craig

Tracks

Diseases and Cures

Terms of Use

ARMINDA Terms of Use

Location

Science 159

Presentation Type

Oral Presentation

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Associations Between the Ankle-Brachial Index and Markers of Arterial Dysfunction and Non-Classical Monocytes in HIV-Infected Individuals

Science 159

Prevalence rates of peripheral arterial disease, a common vascular disease indicative of plaque buildup, have been reported in HIV-infected populations to be as high as 20.7 percent. Although the direct cause is still unknown, many factors have been attributed to this increased risk, including persistent inflammation and immune activation, as well as treatment side effects. Peripheral arterial disease is commonly diagnosed using the ankle-brachial index, which measures a ratio of blood pressures in the limbs. My presentation investigates potential associations between the ankle-brachial index and measurements of arterial dysfunction as well as non-classical monocytes. Results of our research showed that abnormal ankle-brachial index scores were significantly associated with lower levels of non-classical monocytes and increased carotid artery intima-media thickness. This research provides further understanding of the potential role that non-classical monocytes play in the progression of atherosclerosis in HIV-infected individuals.

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