Title

Analyzing Immune Cells in Chronic Graft-Versus-Host Disease

Abstract

High-risk leukemias are very difficult to successfully treat in both children and adults. Stem cell transplants are one treatment method that can cure patients. However, transplantation can cause chronic graft-versus-host disease (cGVHD), a serious and potentially life-threatening side effect. In cGVHD, the transplanted donor immune cells attack the patient’s healthy tissue. Naive T cells are immune cells that have not been activated to target a specific antigen and are implicated in attacking healthy tissue in cGVHD. We analyzed immune cells from patients who received a naive T cell-depleted transplant as a strategy to prevent cGVHD. We sought to identify the proteins that were more highly expressed on immune cells in patients who later developed cGVHD. Our goal was to determine if it is possible to predict which patients are at high risk of cGVHD before its onset for the purpose of treating future transplant recipients prophylactically.

Faculty Sponsor

Matt Craig

Tracks

Diseases and Cures

Terms of Use

ARMINDA Terms of Use

Location

Science 159

Presentation Type

Oral Presentation

Research Funding Source or OCS Program

Whitman College Research Fund for Summer Internships at Fred Hutchinson Cancer Research Center; Cancer Center Support Grant CURE Supplement, National Institutes of Health

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Apr 11th, 11:00 AM Apr 11th, 11:15 AM

Analyzing Immune Cells in Chronic Graft-Versus-Host Disease

Science 159

High-risk leukemias are very difficult to successfully treat in both children and adults. Stem cell transplants are one treatment method that can cure patients. However, transplantation can cause chronic graft-versus-host disease (cGVHD), a serious and potentially life-threatening side effect. In cGVHD, the transplanted donor immune cells attack the patient’s healthy tissue. Naive T cells are immune cells that have not been activated to target a specific antigen and are implicated in attacking healthy tissue in cGVHD. We analyzed immune cells from patients who received a naive T cell-depleted transplant as a strategy to prevent cGVHD. We sought to identify the proteins that were more highly expressed on immune cells in patients who later developed cGVHD. Our goal was to determine if it is possible to predict which patients are at high risk of cGVHD before its onset for the purpose of treating future transplant recipients prophylactically.

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