Title

Searching for the Cure: A Promising HIV Strategy Unlike Any Currently Being Pursued

Abstract

For more than three decades, Human Immunodeficiency Virus (HIV) has posed a challenge for retroviral drug discovery. Despite previous palliative measures to treat the chronic disease, the morbidity of HIV still prevails significantly and will likely continue to increase as the survivors age. Enormous progress has been made in recent decades to uncover how HIV attaches to blood cells, enters inside, replicates and then leaves the cell. However, large gaps remain when it comes to how the virus disassembles itself. Conventional drug discovery platforms approach antiviral therapeutics directly by preventing HIV particles to bind to the host cell. I used an alternative, more indirect approach, one that includes approaching HIV from multiple mechanistic angles, specifically through HIV disassembly. This approach allows one to determine the rippling effects after an initial inciting event has occurred and the following effects it has on all aspects of body regulation.

Faculty Sponsor

Britney Moss

Tracks

Diseases and Cures

Terms of Use

ARMINDA Terms of Use

Location

Science 159

Presentation Type

Oral Presentation

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Searching for the Cure: A Promising HIV Strategy Unlike Any Currently Being Pursued

Science 159

For more than three decades, Human Immunodeficiency Virus (HIV) has posed a challenge for retroviral drug discovery. Despite previous palliative measures to treat the chronic disease, the morbidity of HIV still prevails significantly and will likely continue to increase as the survivors age. Enormous progress has been made in recent decades to uncover how HIV attaches to blood cells, enters inside, replicates and then leaves the cell. However, large gaps remain when it comes to how the virus disassembles itself. Conventional drug discovery platforms approach antiviral therapeutics directly by preventing HIV particles to bind to the host cell. I used an alternative, more indirect approach, one that includes approaching HIV from multiple mechanistic angles, specifically through HIV disassembly. This approach allows one to determine the rippling effects after an initial inciting event has occurred and the following effects it has on all aspects of body regulation.

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