Title

Delineating the Path Through Which Fibroblast Growth Factors Produce Remission from Type 2 Diabetes

Abstract

Since the discovery of insulin in 1921, therapies for Diabetes mellitus focus on pancreatic islets in an attempt to normalize blood glucose levels and stall disease progression. However, in the 19th century, the central nervous system was implicated in the pathology and potential therapy of diabetes. This presentation focuses on a return to the CNS as a way of treating diabetes via the family of Fibroblast Growth Factors. FGFs, specifically FGF1, 19 and 21, have been implicated in the prolonged lowering of blood glucose levels in rodent models, offering a potential CNS-focused therapy. This study aims to delineate the FGF1 signaling cascade by looking at effects of a mutant FGF, R50. We found that by comparing the effects of FGF1 and R50 on rodent models of diabetes we could further delineate the mechanism by which FGF1 works to produce remission.

Faculty Sponsor

Paul Yancey

Tracks

Diseases and Cures

Terms of Use

ARMINDA Terms of Use

Location

Science 159

Presentation Type

Oral Presentation

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Delineating the Path Through Which Fibroblast Growth Factors Produce Remission from Type 2 Diabetes

Science 159

Since the discovery of insulin in 1921, therapies for Diabetes mellitus focus on pancreatic islets in an attempt to normalize blood glucose levels and stall disease progression. However, in the 19th century, the central nervous system was implicated in the pathology and potential therapy of diabetes. This presentation focuses on a return to the CNS as a way of treating diabetes via the family of Fibroblast Growth Factors. FGFs, specifically FGF1, 19 and 21, have been implicated in the prolonged lowering of blood glucose levels in rodent models, offering a potential CNS-focused therapy. This study aims to delineate the FGF1 signaling cascade by looking at effects of a mutant FGF, R50. We found that by comparing the effects of FGF1 and R50 on rodent models of diabetes we could further delineate the mechanism by which FGF1 works to produce remission.

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