Title

Microwave Assisted Syntheses of CB11- Carborane Derivatives

Abstract

Derivatives of the 1-carba-closo-dodecaborane(-1) carborane anion (CB11-) have a variety of potential applications which include use as therapeutic agents, catalysts, medical imaging agents and weakly coordinating anions. A new microwave assisted synthesis of the undecachlorinated derivative (CHB11Cl11-) has been developed. This compound has synthetic application as a weakly coordinating anion for cationic catalytic processes, but currently its accessibility is limited by a lengthy synthesis. A novel synthesis of the monoesterified derivative, 12-COOCH2CH3-CHB11H10 has also been developed from the previously established carboxylic acid derivative. With this synthesis carboxylic acid derivatives can be readily converted into a variety of esterified products. Reaction with select biomolecules could be a delivery mechanism of B10 to cancer cells for Boron Neutron Capture Therapy (BNCT).

Faculty Sponsor

Mark Juhasz

Tracks

Micro-science

Terms of Use

ARMINDA Terms of Use

Location

Science 159

Presentation Type

Oral Presentation

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Microwave Assisted Syntheses of CB11- Carborane Derivatives

Science 159

Derivatives of the 1-carba-closo-dodecaborane(-1) carborane anion (CB11-) have a variety of potential applications which include use as therapeutic agents, catalysts, medical imaging agents and weakly coordinating anions. A new microwave assisted synthesis of the undecachlorinated derivative (CHB11Cl11-) has been developed. This compound has synthetic application as a weakly coordinating anion for cationic catalytic processes, but currently its accessibility is limited by a lengthy synthesis. A novel synthesis of the monoesterified derivative, 12-COOCH2CH3-CHB11H10 has also been developed from the previously established carboxylic acid derivative. With this synthesis carboxylic acid derivatives can be readily converted into a variety of esterified products. Reaction with select biomolecules could be a delivery mechanism of B10 to cancer cells for Boron Neutron Capture Therapy (BNCT).

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