Title

Gene Expression of the EGF Pathway in the Nematode C. elegans

Abstract

The Epidermal Growth Factor pathway in the nematode Caenorhabditis elegans influences different aspects of physiology, including vulva development, increased lifespan and lipid synthesis. The mechanism by which it controls lipid synthesis is still not completely understood. One aspect yet to be fully explained is the effect of EGF signaling on lipid gene expression. I grew strains with different levels of EGF signaling, from low to high, and conducted a qPCR analysis of lipid gene expression in those strains. I also analyzed lipid gene expression in an sbp-1 mutant, a key component in the control of lipid synthesis. My research will lead to a broader understanding of the role EGF signaling in lipid synthesis pathways. Given that these metabolic processes are highly conserved in animals, this work has implications for human physiology including potential insights into ways to combat obesity and cancer.

Faculty Sponsor

Matthew Crook

Tracks

poster

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Location

Cordiner Hall

Presentation Type

Poster

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Apr 11th, 1:00 PM Apr 11th, 2:00 PM

Gene Expression of the EGF Pathway in the Nematode C. elegans

Cordiner Hall

The Epidermal Growth Factor pathway in the nematode Caenorhabditis elegans influences different aspects of physiology, including vulva development, increased lifespan and lipid synthesis. The mechanism by which it controls lipid synthesis is still not completely understood. One aspect yet to be fully explained is the effect of EGF signaling on lipid gene expression. I grew strains with different levels of EGF signaling, from low to high, and conducted a qPCR analysis of lipid gene expression in those strains. I also analyzed lipid gene expression in an sbp-1 mutant, a key component in the control of lipid synthesis. My research will lead to a broader understanding of the role EGF signaling in lipid synthesis pathways. Given that these metabolic processes are highly conserved in animals, this work has implications for human physiology including potential insights into ways to combat obesity and cancer.

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