Title

The Role of lin-35, cdc-25, and cul-1 in LET-23 Mediated Suppression of Cell Death

Abstract

Cell signaling pathways involved in the suppression of cell death play an important role in understanding human cancer. Learning the mechanisms behind these pathways can provide important insights into how and why tumors form. LET-23 is the receptor in the epidermal growth factor signaling pathway, which is critical for development in C. elegans. Recent studies have also found that LET-23 can play a role in suppressing cell death, but the specific mechanisms controlling the suppression are still largely unknown. CDK-2, a cyclin dependent kinase that helps control the cell cycle, is necessary for LET-23 mediated suppression. Using RNAi, we knock down the expression of lin-35, a downstream target gene of CDK-2, and two upstream regulators, cdc-25 and cul-1. Studying the effect of RNAi knockdown on these three genes will help us gain a better understanding of the LET-23 pathway and how it suppresses cell death.

Faculty Sponsor

Matthew Crook

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poster

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Location

Cordiner Hall

Presentation Type

Poster

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The Role of lin-35, cdc-25, and cul-1 in LET-23 Mediated Suppression of Cell Death

Cordiner Hall

Cell signaling pathways involved in the suppression of cell death play an important role in understanding human cancer. Learning the mechanisms behind these pathways can provide important insights into how and why tumors form. LET-23 is the receptor in the epidermal growth factor signaling pathway, which is critical for development in C. elegans. Recent studies have also found that LET-23 can play a role in suppressing cell death, but the specific mechanisms controlling the suppression are still largely unknown. CDK-2, a cyclin dependent kinase that helps control the cell cycle, is necessary for LET-23 mediated suppression. Using RNAi, we knock down the expression of lin-35, a downstream target gene of CDK-2, and two upstream regulators, cdc-25 and cul-1. Studying the effect of RNAi knockdown on these three genes will help us gain a better understanding of the LET-23 pathway and how it suppresses cell death.

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