Title

The Heating Dilemma: Designing a Low-Cost, Low-Resource Thermal Molecular Diagnostic Tool for HIV and HPV

Abstract

Microfluidic devices have emerged as a leading contender in point-of-care diagnostics for specific diseases in resource-limited settings. These small plastic devices pass extremely small quantities of liquid through micro-channels to perform many different cellular-based experiments. The Chiu research group at the University of Washington has been investigating microfluidic devices for the diagnosis of HIV and HPV in low-resource settings. My research looked at the usage of a phase change material to control heating of isothermal DNA amplification to detect viral DNA. The results yielded promising heating data that demonstrated the designed heating device could indeed maintain the proper operating temperature for isothermal DNA amplification. Combined with other modules, the final diagnostic device could give healthcare providers a critical tool in the fight against the morbidity and mortality caused by these two infectious diseases.

Faculty Sponsor

Britney Moss

Tracks

poster

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Location

Cordiner Hall

Presentation Type

Poster

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Apr 11th, 1:00 PM Apr 11th, 2:00 PM

The Heating Dilemma: Designing a Low-Cost, Low-Resource Thermal Molecular Diagnostic Tool for HIV and HPV

Cordiner Hall

Microfluidic devices have emerged as a leading contender in point-of-care diagnostics for specific diseases in resource-limited settings. These small plastic devices pass extremely small quantities of liquid through micro-channels to perform many different cellular-based experiments. The Chiu research group at the University of Washington has been investigating microfluidic devices for the diagnosis of HIV and HPV in low-resource settings. My research looked at the usage of a phase change material to control heating of isothermal DNA amplification to detect viral DNA. The results yielded promising heating data that demonstrated the designed heating device could indeed maintain the proper operating temperature for isothermal DNA amplification. Combined with other modules, the final diagnostic device could give healthcare providers a critical tool in the fight against the morbidity and mortality caused by these two infectious diseases.

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