Title

Measuring Cytogenetic Aberrations Induced by Accelerated Helium Ions

Abstract

Galactic cosmic radiation poses a cancer risk for astronauts assigned to long-term missions because the radiation encountered in space can damage DNA. Our lab is analyzing the effects of helium radiation on the epithelial cells of intact mouse kidneys at 0cG (centigrays), 21cG, 42cG, and 168cG. The amount of aberrations is expected to increase as the dose increases. Our results confirm that a higher dose of helium ion radiation increases chromosomal aberrations within the cells. The difference in percent of cells with aberrations in the 0cG and the 168cG cells was found to be statistically significant by the Fisher’s Exact Test. A significant difference was also found between the average aberration per cell and average chromosome break per cell at 0 cG and 168cG. These results help quantify the risk posed to cells by one type of radiation encountered during space exploration.

Faculty Sponsor

Arielle Cooley

Tracks

poster

Terms of Use

If you have questions about permitted uses of this content, please contact the ARMINDA administrator

Location

Cordiner Hall

Presentation Type

Poster

Research Funding Source or OCS Program

Oregon Institute of Occupational Health Sciences

This document is currently not available here.

Share

COinS
 
Apr 11th, 1:00 PM Apr 11th, 2:00 PM

Measuring Cytogenetic Aberrations Induced by Accelerated Helium Ions

Cordiner Hall

Galactic cosmic radiation poses a cancer risk for astronauts assigned to long-term missions because the radiation encountered in space can damage DNA. Our lab is analyzing the effects of helium radiation on the epithelial cells of intact mouse kidneys at 0cG (centigrays), 21cG, 42cG, and 168cG. The amount of aberrations is expected to increase as the dose increases. Our results confirm that a higher dose of helium ion radiation increases chromosomal aberrations within the cells. The difference in percent of cells with aberrations in the 0cG and the 168cG cells was found to be statistically significant by the Fisher’s Exact Test. A significant difference was also found between the average aberration per cell and average chromosome break per cell at 0 cG and 168cG. These results help quantify the risk posed to cells by one type of radiation encountered during space exploration.

Rights Statement

Rights Statement

In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).